Santa Cruz Vacation Packages

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Your Santa Cruz Vacation

With a Santa Cruz vacation package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz vacation. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.

Top vacation destinations in Santa Cruz

FlightsFlightsHotelsHotels

Santa Cruz

Santa Cruz
Mountain view in Samaipata, Florida Province of the Santa Cruz Department, Bolivia
FlightsFlightsHotelsHotels

Samaipata

Samaipata

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is CA $81 per night from May 15 to May 16
CA $81
CA $81 total
May 15 - May 16
9.6/10 Exceptional! (111 reviews)
Although the room was clean, it was very musty and wet smelling. Even with the air conditioner running, it did not seem to help. I found it difficult to communicate with the property, even in Spanish, because it took a long time for messages to be answered and the phone numbers for the property did ...

Reviewed on May 6, 2026

Ibis Santa Cruz DE LA Sierra
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is CA $148 per night from May 12 to May 13
CA $148
CA $148 total
May 12 - May 13
8.2/10 Very Good! (372 reviews)
The airport shuttle did not meet us after our flight, even though I had contacted the hotel in advance and they confirmed pick up. Very disappointing. The shuttle did take us back to the airport which was convenient. The hotel is terrible at responding to guests in advance if a stay. They eventually ...

Reviewed on May 1, 2026

Sun Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is CA $185 per night from Jun 3 to Jun 4
CA $185
CA $185 total
Jun 3 - Jun 4
9/10 Wonderful! (376 reviews)
Nice hotel

Reviewed on May 8, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
See all 318 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Santa Cruz vacation package cost?
We make it simple to travel the world, with Santa Cruz vacation packages starting from as little as . You'll have the flexibility to combine your favorite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cozy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz vacation?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favorite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz vacation package is the most convenient way to organize your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz vacation package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.

Discover the most popular places to visit in Santa Cruz

Plaza 24 de Septiembre

Plaza 24 de Septiembre

5/5(5 reviews)

The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

Plaza 24 de Septiembre

Ventura Mall

4.5/5(3 reviews)

During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.

Ventura Mall

Guembe Biocenter

5/5(1 review)

Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.

Guembe Biocenter

What to do in Santa Cruz

Santa Cruz: Wildlife Sanctuary and Preservation Park Tour

Santa Cruz: Wildlife Sanctuary and Preservation Park Tour

CA $117
per adult
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
Vallegrande City

Vallegrande City Tour

CA $40
per adult
Vallegrande City Tour
Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande

Guided visit to the Che Guevara Memorial in Vallegrande

CA $26
per adult
Guided visit to the Che Guevara Memorial in Vallegrande
See all activities in Santa Cruz
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.