Santa Cruz Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Santa Cruz Vacation
With a Santa Cruz vacation package, you can forget about planning hassles and simply focus on experiencing everything this thrilling destination has to offer. The best way to plan your trip to Santa Cruz is to begin with its most popular cities, which include Samaipata, Roboré and Camiri. Expedia is a one-stop shop when it comes to planning your Santa Cruz vacation. From flights and hotels, to activities and more, we're here to help you create a travel experience like no other.
Top vacation destinations in Santa Cruz
Santa Cruz
Samaipata
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most.
Hamacas
While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.
Santa Cruz Hotel Deals
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
CA $47
CA $47 total
Aug 24 - Aug 25
9.4/10 Exceptional! (131 reviews)
"Great deal"
Reviewed on Aug 1, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
CA $177
CA $177 total
Aug 16 - Aug 17
9/10 Wonderful! (399 reviews)
"Como siempre el Mejor nivel para estancias en Santa Cruz"
Reviewed on Aug 8, 2026
Marriott Santa Cruz de la Sierra Hotel
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
CA $147
CA $147 total
Aug 14 - Aug 15
9/10 Wonderful! (242 reviews)
"Everything was great. Came for a business trip and would stay here again."
Reviewed on Aug 7, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Cruz vacation package cost?
We make it simple to travel the world, with Santa Cruz vacation packages starting from as little as . You'll have the flexibility to combine your favorite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cozy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz vacation?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favorite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz vacation package is the most convenient way to organize your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz vacation package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.
Stay near popular Santa Cruz attractions
Plaza 24 de Septiembre
8.8/10 (164 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
San Lorenzo Cathedral
9.0/10 (84 reviews)
One of the most iconic landmarks in Santa Cruz is the city’s mighty cathedral, which houses a museum displaying important artwork.
Ventura Mall
9.0/10 (183 reviews)
During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Guembe Biocenter
8.8/10 (60 reviews)
Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.
Santa Cruz Zoo
8.4/10 (53 reviews)
Why not visit the native and exotic animals who call Santa Cruz Zoo home during your vacation in Santa Cruz? While in the area, you can find time to visit its shops.
Cine Center
8.0/10 (53 reviews)
You can get tickets for a performance at Cine Center during your trip to Santa Cruz. While in the area, you can find time to visit its shops.
Ramon Tahuichi Aguilera Stadium
8.4/10 (18 reviews)
Catch an event at Ramon Tahuichi Aguilera Stadium during your trip to Santa Cruz. While in the area, you can find time to visit its shops.
Lomas de Arena Regional Park
8.4/10 (28 reviews)
Explore the great outdoors at Lomas de Arena Regional Park, a lovely green space in Santa Cruz. While in the area, you can find time to visit its shops.
What to do in Santa Cruz
Santa Cruz and Porongo: History, Markets, River, and Culture
CA $91
per adult
Private Historical Expedition: The Che Legacy in Vallegrande
CA $27
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
